Welcome to SIMPLER!

A research infrastructure for a healthy life - Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research

SIMPLER - A research infrastructure for a healthy life

Swedish Infrastructure for Medical Population-based Life-course and Environmental Research - SIMPLER

The infrastructure's mission is to provide national and international researchers with data for studies on how dietary and lifestyle factors and genetics affect our health, especially during the latter part of life. The knowledge can for example be used to develop recommendations on diet and lifestyle, develop new markers fore easier and more accurate diagnosis of chronic diseases and their precursors and to develop new individualized treatments.

Two cohorts form the basis of SIMPLER, the Swedish Mammography Cohort and the Cohort of Swedish Men. Almost 110 000persons are included in the two cohorts. The participants have answered questionnaires with questions on health, diet and lifestyle at repeated occasions. Two subgroups have also visisted clinics in Uppsala and Västerås for biometric measurements and sampling. Analysis of collected samples have provided the infrastructure with several types of data such as iron, glucose and blood fat levels, but also proteins and metabolites in the blood stream in addition to genetic variation and gut microbiota.

SIMPLER's smorgasbord with data and samples are availble for reserach via an application process. Criteria for use of SIMPLER data is for example en ethical approval from the Swedish Ethical Reviw Board and a clear and relevant research questions. Researchers in academia as well as buisness are welcome to apply for a project in SIMPLER.

Bilden visar en schematisk bild över de olika byggstenarna i SIMPLER.
SIMPLER's smorgasbord consists of data and samples available for research.

Metabolic biomarker profiling Nightingale Health

During 2023 blood samples from the clinical cohorts have been analysed by Nightingale Health, Finland. Data for ca 250 metabolites using NMR (Nuclear Magnetic Resonance) is now available.

The clinical subkohort Uppsala 20 year

In November we celebrated 20 years since the first visit of the first participant in the clinical subcohort SMC Uppsala. We marked the occasion with cake!

Since November 2003, another visit has been made by approx. 1,800 of the first approx. 5,000 participants and during the autumn we have started to invite participants for a third visit.

Continued funding from the Swedish Research Council

On 3 February 2022, the Swedish Research Council’s Council for Research Infrastructures (RFI) decided to continue funding SIMPLER between 2023 and 2028.


Region uppsala Region Örebro län Region västmarland Karolinska institutet Uppsala universitet Örebro universitetChalmers

Swedish National Infrastructures

Some Swedish national infrastructures with resources that may be of interest

Comparative Research Center Sweden, CORS

The National E-infrastructure for Aging Research, NEAR

Relations, Work and Health across the life-course ─ A Research Data Infrastructure, REWHARD

Swedish Twin Registry

Swedish Population Databases for Research, SwedPop

Evaluation Through Follow-up, UGU

Last modified: 2023-12-01