Swedish Mammography Cohort Clinical

A clinical examination of a subcohort of the Swedish Mammography Cohort living in Uppsala was conducted between 2003 and 2009. The cycle of re-examination started in year 2013 and is ongoing. A clinical examination of women in Västerås were conducted between 2010 and 2019. The examination includes collection of clinical samples and additional information.

The Swedish Mammography Cohort Clinical Uppsala

From 2003 through 2009 participants in the Swedish Mammography Cohort below age 85 years and living in the town of Uppsala were randomly selected and invited to participate in a clinical subcohort. Of the 8,311 invited women 65% answered the received diet, lifestyle, and physical activity questionnaire and 60%, 5,037, participated in the health examination. The health examination included weight, height, waist, hip, and blood pressure measurements, and body composition measurement using a dual energy X-ray absorptiometry (DEXA) scan. Samples of fasting blood, urine, fecal sample and adipose tissue were also collected at the health exam.

A subset of these women completed an additional FFQ and a physical activity questionnaire and wore a physical activity monitor and completed a 7-day activity record. A second subset of women completed a questionnaire on sun exposure in conjunction with a blood sample collected both during winter and summer months.

A second health examination including biological sample collection, and diet and lifestyle questionnaire, is ongoing for this clinical subcohort since November 2013. The second round also includes a one-day food diary and a cognitive interview.

Home health examination Uppsala

From March 2012 to March 2013 1,030 women in the Swedish Mammography Cohort over age 85 years and living in Uppsala County received an invitation letter to participate in a validated cognitive test phone interview, complete a FFQ, and receive a home health examination. 305 women, 29%, were examined at home including weight, height, waist, hip, and blood pressure measurements, blood, urine, adipose tissue, and fecal sample collection, a physical function test, and the Mini Mental State Examination (MMSE).

The Swedish Mammography Cohort Clinical Västerås

Between 2010 and 2019 women in the Swedish Mammography Cohort living in the county of Västmanland and together with a man in the Cohort of Swedish Men received a diet, health and lifestyle questionnaire and a one-day food diary with an invitation to participate in a health examination. During the nine years a total of 2,627 women visited the clinic in Västerås of which 1,062 can be associated with a COSM-man. The health examination included weight, height, waist, hip, blood pressure measurement and body composition measurement using a bio-electrical impedance scale (Tanita, Tokyo, Japan). Samples of fasting blood, urine, fecal sample and adipose tissue were also collected at the health exam.

A second round is planned to start during late 2019 or early 2020 with the same procedure as the first round with the addition of a cognitive interview.