Swedish Mammography Cohort Subcohorts
A health examination of women in SMC living in Uppsala was conducted between 2003 and 2009 at the research clinic. The cycle of re-examination for this group started in 2015 and is ongoing. For women living in Västerås, a health examination was conducted between 2010 and 2019. The examination includes biometric mesaurements and collection of biological samples.
Swedish Mammography Cohort Clinical Uppsala (SMCC Uppsala)
From 2003 through to 2009, a subset of women in SMC below the age of 85 and living in the city of Uppsala were randomly selected and invited to participate in a health examination, forming the Swedish Mammography Cohort Clincal Uppsala (SMCC Uppsala). Of the 8,311 invited women, 65 % answered the received diet, lifestyle, and physical activity questionnaire and 60 %, 5,032 women, participated in the health examination. Samples are available for 5,022 women. The health examination included weight, height, waist, hip, and blood pressure measurements, as well as a body composition measurement using a dual energy X-ray absorptiometry (DXA) scan. Samples of fasting blood and urine, and adipose tissue were also collected at the health exam.
A subset of SMCC women who visited the clinic completed additional food and physical activity questionnaires. Furthermore, they wore physical activity monitors and completed a 7-day activity record. A second subset of SMCC women who visited the clinic completed a questionnaire on sun exposure in conjunction with a blood sample collected both during winter and summer months.
A second round of health examination which includes biological sample collection (blood, urine, adipose tissue, and stool) and a diet and lifestyle questionnaire between 2015 and 2023. The second round also includes a 1-day food diary and a cognitive interview.
Home health examination Uppsala
From March 2012 to March 2013, 1,030 women in SMC over the age of 85 and living in Uppsala county received an invitation to participate in a validated cognitive-test phone interview, complete a food frequency questionnaire, and receive a home health examination. 305 women, 29 %, were examined in their homes. The examination included taking weight, height, waist, hip, and blood pressure measurements, a physical function test, and the Mini Mental State Examination (MMSE). Blood, urine, adipose tissue, and stool samples were also collected.
Swedish Mammography Cohort Clinical Västerås (SMCC Västerås)
Between 2010 and 2019, women in SMC living in the county of Västmanland received a diet, health, and lifestyle questionnaire as well as a 1-day food diary, along with an invitation to participate in a health examination. During the 9 years, a total of 2,630 women visited the clinic in Västerås, of which 1,062 were living with a man participating in the male subcohort of COSM. The health examination included weight, height, waist, hip, blood pressure measurements, and body composition measurements using a bio-electrical impedance scale. Samples of fasting blood, urine, stool samples, and adipose tissue were also collected at the health exam.
A second round of testing started in October 2023, following the same procedure as the first round, but adding a cognitive interview and a DXA scan for all participants at their visit.